1776 E-CADHERIN, N-CADHERIN AND TWIST EXPRESSION IN HIGH RISK BLADDER CANCER

You have accessJournal of UrologyBladder Cancer: Superficial II1 Apr 20121776 E-CADHERIN, N-CADHERIN AND TWIST EXPRESSION IN HIGH RISK BLADDER CANCER Marc Vergnolles, Gregoire Robert, Philippe Ballanger, Jean-Marie Ferriere, Gilles Pasticier, Alain Ravaud, Nadine Houede, Jean-Christophe Bernhard, and Herve Wallerand Marc VergnollesMarc Vergnolles Bordeaux, France More articles by this author , Gregoire RobertGregoire Robert Bordeaux, France More articles by this author , Philippe BallangerPhilippe Ballanger Bordeaux, France More articles by this author , Jean-Marie FerriereJean-Marie Ferriere Bordeaux, France More articles by this author , Gilles PasticierGilles Pasticier Bordeaux, France More articles by this author , Alain RavaudAlain Ravaud Bordeaux, France More articles by this author , Nadine HouedeNadine Houede Bordeaux, France More articles by this author , Jean-Christophe BernhardJean-Christophe Bernhard Bordeaux, France More articles by this author , and Herve WallerandHerve Wallerand Bordeaux, France More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1793AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Epithelial-mesenchymal transition is a complex process taking place during embryonic development in which cell–cell and cell-extracellular matrix interactions are altered. Malignant cells exploit this “normal” process in order to invade and metastasize with a loss of expression of E-cadherin and neo expression of N-cadherin. Twist is an inhibitor of the expression of E-cadherin and would be an anti-apoptotic agent. Prognosis of high-risk non-muscle-invasive bladder cancer is poor when progressing in muscle-invasive. METHODS This monocentric retrospective study concerned 123 patients with a primary T1 high grade tumor, single and <3cm. Expression of intercellular adhesion proteins E-cadherin, N-cadherin and Twist were studied with immunochemistry. RESULTS Loss of expression of E-cadherin was 71.5% and was correlated with CIS (p=0.01). Neo expression of N-cadherin (8.9%) was correlated with progression (p<0,01) and poor specific survival(p<0,01). Twist expression (17.1%) was correlated with progression (p<0,02). None of the markers expression increased the risk of recurrence. Combining markers allowed to define favorable profil (E+/N-/T-) and unfavorable (E-/N+/T+). CONCLUSIONS Profils E-/N+/T+ and E-/N+ are associated with a high risk of progression and a radical treatment (an early cystectomy) could be proposed. Targeted therapies anti N-cadherin or anti-Twist could reduce the risk of progression and restore chemosensitivity. Larger studies are necessary to validate these markers. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e717 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Marc Vergnolles Bordeaux, France More articles by this author Gregoire Robert Bordeaux, France More articles by this author Philippe Ballanger Bordeaux, France More articles by this author Jean-Marie Ferriere Bordeaux, France More articles by this author Gilles Pasticier Bordeaux, France More articles by this author Alain Ravaud Bordeaux, France More articles by this author Nadine Houede Bordeaux, France More articles by this author Jean-Christophe Bernhard Bordeaux, France More articles by this author Herve Wallerand Bordeaux, France More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...