2191 MONITORING BRAIN ACTIVITY USING FMRI DURING BLADDER FILLING AND PELVIC FLOOR MUSCLE CONTRACTIONS

You have accessJournal of UrologyImaging/Radiology: Uroradiology (II)1 Apr 20132191 MONITORING BRAIN ACTIVITY USING FMRI DURING BLADDER FILLING AND PELVIC FLOOR MUSCLE CONTRACTIONS Jan Krhut, Petr Holý, Jaroslav Tintera, Peter Zvara, and Roman Zachoval Jan KrhutJan Krhut Ostrava, Czech Republic More articles by this author , Petr HolýPetr Holý Prague, Czech Republic More articles by this author , Jaroslav TinteraJaroslav Tintera Prague, Czech Republic More articles by this author , Peter ZvaraPeter Zvara Burlington, VT More articles by this author , and Roman ZachovalRoman Zachoval Prague, Czech Republic More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2100AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to map brain activity with function magnetic resonance imaging (fMRI) during bladder filling and pelvic floor muscle (PF) contractions, using a refined scanning protocol along with synchronous urodynamics. METHODS A total of 23 healthy female volunteers (age 20?68 years) were enrolled. Participants were asked to contract their pelvic floor muscles. This was followed by a standard urodynamic examination consisting of repeated filling cycles. Brain activity was measured by fMRI using a 3T MR system. Measurements of brain activity consisted of 120 dynamic scans during pelvic floor contractions and 210 dynamics during bladder filling. Each fMRI dynamic covered the brain with 35 slices. Statistical analyses employed the General Linear Module and Independent Component Analysis. Areas of activation were visualized using group statistics. RESULTS The following main clusters of activation were observed during PF contractions: medial surface of the frontal lobe (primary motor area), bilaterally; supplementary motor area, bilaterally; and left gyrus precentralis. During bladder filling, activation was detected in the inferior frontal lobe bordering the frontal cingulum, left gyrus parietalis superior, left central area, brainstem, and thalamus with subcortical gray matter nuclei. CONCLUSIONS This study extended an existing fMRI protocol used to record central neural control of the lower urinary tract (LUT). These results are consistent with the available literature and agree with the present hypothetical functional model of LUT neural control. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e898-e899 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jan Krhut Ostrava, Czech Republic More articles by this author Petr Holý Prague, Czech Republic More articles by this author Jaroslav Tintera Prague, Czech Republic More articles by this author Peter Zvara Burlington, VT More articles by this author Roman Zachoval Prague, Czech Republic More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...