Synthesis of 1′-C-Cyano Pyrimidine Nucleosides and Characterization as HCV Polymerase Inhibitors

Thorsten A Kirschberg,Michael Mish,Neil H Squires,Sebastian Zonte,Evangelos Aktoudianakis, Samuel E Metobo,Thomas Butler, Xie Ju,Aesop Cho,Adrian S Ray,Choung U Kim

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2015）

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摘要

Ribose modified 1-C-cyano pyrimidine nucleosides were synthesized. A silver triflate mediated Vorbruggen reaction was used to generate the nucleoside scaffold and follow-up chemistry provided specific ribose modified analogs. Nucleosides and phosphoramidate prodrugs were tested for their anti-HCV activity.

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关键词

Nucleosides,1-cyano pyrimidine nucleosides,HCV

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