Determination and prediction of solubilities of active pharmaceutical ingredients in selected organic solvents

Hiroyuki Matsuda, Kanako Mori, Mariko Tomioka, Nozomi Kariyasu,Toshiro Fukami,Kiyofumi Kurihara,Katsumi Tochigi,Kazuo Tomono

Fluid Phase Equilibria（2015）

引用 38|浏览11

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摘要

•This study investigates measurements of solubilities of APIs.•Solubilities of APIs in different organic solvents were measured.•Solubilities of famotidine with two polymorphs were also investigated.•Experimental solubility data were represented by NRTL and UNIQUAC models.•Solubilities of salicylic acid were predicted by Pharma Modified UNIFAC.

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关键词

Solubility,Pharmaceutical compounds,Polymorphs,Activity coefficient model,Prediction

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