Melanocytic nevi excised during B-Raf proto-oncogene (BRAF) inhibitor therapy: A study of 19 lesions from 10 patients

Mark C Mochel,Marc R Hammond,Dennie T Frederick,Maria B Alorapalli,Adriano Piris,Keith T Flaherty,Mai P Hoang

Journal of the American Academy of Dermatology（2015）

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摘要

The nevi associated with BRAF inhibitor therapy invariably lack BRAFV600E mutation. BRAF inhibition appears to cause an increased cytotoxic T-cell response and increased mitogen-activated protein kinase activity in BRAF wild-type lesions, supported by pERK expression, possibly resulting in an activated phenotype characterized by increased melanin pigmentation and deep HMB-45 expression.

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关键词

B-Raf proto-oncogene inhibition,CD4,CD8,melanocytic nevi,phosphorylated extracellular signal-regulated kinase,phosphorylated protein kinase B

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