A NEW 2H2O-METABOLIC LABELING METHOD REVEALS HETEROGENEOUS ALTERATIONS OF PROTEIN TURNOVER IN THE FAILING HEART

Felix Woitek,Ling Li,Jeffery C Powers,Marykathryn Hurst, Lien P Ly, A Kulczycki,Amy Lam,Isabel Ottiger,Belinda Willard,William C Stanley,Fabio A Recchia,Takhar Kasumov

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY（2014）

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摘要

The altered myocardial protein turnover is considered a major pathogenic factor in heart failure (HF), however studies performed with standard molecular analysis have provided only indirect and discordant evidence of this phenomenon. Direct measurements of the rate of in vivo protein turnover are

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关键词

failing heart,protein turnover,o-metabolic

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