Suppressors of superoxide production from mitochondrial complex III

Adam L Orr,Leonardo Vargas,Carolina N Turk, Janine E Baaten,Jason T Matzen, Victoria J Dardov, Stephen J Attle, Jing Li, Douglas C Quackenbush,Renata L S Goncalves,Irina V Perevoshchikova,H Michael Petrassi,Shelly L Meeusen,Edward K Ainscow,Martin D Brand

NATURE CHEMICAL BIOLOGY（2015）

引用 131|浏览25

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摘要

High-throughput chemical screening identified several groups of compounds that selectively block superoxide production from the outer Q-binding site of mitochondrial complex III and protect against ROS-induced oxidative stress in pancreatic β cells.

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关键词

small molecules,high throughput screening,biochemistry,metabolism

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