Studies on the Reactions Between the DNA Bases and a Model Α,β-Unsaturated Oxoaldehyde

Two sets of adducts of 2′-dC with a model oxoenal were characterised based on 2D NMR spectroscopy. DFT calculations indicated that two mechanisms can be involved in these compounds formation. The instability of one of these products leads to deamination of 2′-dC.