Persistent Sydenham's chorea is not associated with sustained lymphocyte dysfunction.

The mechanisms involved in the symptoms of Sydenham's chorea (SC) remain obscure. Taking into account the autoreactive antibody-mediated hypothesis of SC pathogenesis, the persistence of chorea may be associated with increased levels of B1 lymphocytes and other lymphocyte subsets. We evaluated lymphocyte subsets, including B1 and T cells, in patients with remitted (RSC) and persistent (PSC) SC by flow cytometry. Our results showed neither difference in the frequency of T and B lymphocytes subpoputations nor in their activation and functional states.These findings undermine the view of PSC as a sustained cytotoxic cellular-mediated condition.Alternative mechanisms may explain the pathogenesis of PSC.