1 H, 15 N and 13 C backbone assignments of GDP-bound human H-Ras mutant G12V
Biomolecular NMR assignments(2015)
摘要
Harvey Ras (H-Ras) is a membrane-associated GTPase with critical functions in cell proliferation and differentiation. The G12V mutant of H-Ras is one of the most commonly encountered oncoproteins in human cancer. This mutation disrupts the GTPase activity of H-Ras, leading to constitutive activation and aberrant downstream signalling. Here we report the backbone resonance assignments of human H-Ras mutant G12V lacking the C-terminal membrane attachment domain.
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关键词
Cancer,H-Ras,H-Ras G12V,NMR,NMR resonance assignments,Ras
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