Real-Time Monitoring and Control of Critical Process Impurities During the Manufacture of Fostamatinib Disodium
Organic process research & development(2015)
摘要
Process analytical technology (PAT) was used to probe, monitor, and control the formation of process impurities during the synthesis of a pharmaceutical intermediate at 600 kg input scale. An accurate determination of end of reaction (EoR) was vital in limiting side-products, and a novel inline UV/vis-based approach was used where more traditional EoR techniques had failed.
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