Requirement of argininosuccinate lyase for systemic nitric oxide production

NATURE MEDICINE, pp. 1619-U134, 2011.

Cited by: 73|Views14

Abstract:

Nitric oxide (NO) is crucial in diverse physiological and pathological processes. We show that a hypomorphic mouse model of argininosuccinate lyase (encoded by Asl) deficiency has a distinct phenotype of multiorgan dysfunction and NO deficiency. Loss of Asl in both humans and mice leads to reduced NO synthesis, owing to both decreased end...More

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