The Leishmania donovani peroxin 14 binding domain accommodates a high degeneracy in the pentapeptide motifs present on peroxin 5

•LdPEX14 binds the pentapeptide motif with the consensus sequence [W/F/L]XXX[W/F/L].•The LdPEX5–LdPEX14 interaction mediated by W293AQEY297 pentapeptide motif.•LdPEX5 and LdPEX14 association is stabilized by dimer–dimer contacts.