Viral Vector Delivery of Env Trimer Immunogens
Retrovirology(2012)
摘要
Methods We are using vesicular stomatitis virus (VSV) as a vector platform for delivery of Env immunogens as transmembrane glycoproteins. We have investigated a variety of vector designs and Env modifications to identify combinations that balance the practical requirement for vector genetic stability with factors influencing antibody responses including immunogen abundance, efficient post-translational processing, and presentation of antigenic determinants representative of a functional trimeric spike.
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关键词
Vesicular Stomatitis Virus,Cell Plasma Membrane,Immunogenicity Study,Glycoprotein Spike,Mucosal Antibody
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