P53 Genetic Polymorphisms, Interactions With Lifestyle Factors And Lung Cancer Risk In A Chinese Population.

Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: A GWAS study suggested rs2078486 was a novel functional p53 SNP, but very few studies replicate this association. P53 rs1042522 is the most commonly studied SNP, but very few studies examined its potential interaction with environmental factors in relation to lung cancer risk. This study aims to examine associations between two p53 single-nucleotide polymorphisms (SNPs) (rs2078486, rs1042522), their potential interaction with environmental factors and risk of lung cancer. Methods: A case-control study was conducted in Taiyuan, China. Unconditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs). Multiplicative and additive interactions between p53 SNPs and lifestyle factors were evaluated. Results: Variant p53 rs2078486 SNP was significantly associated with elevated lung cancer risk among smokers (OR: 1.70, 95% CI: 1.08 - 2.67) and individuals with high indoor air pollution exposure (OR: 1.51, 95% CI: 1.00-2.30). Significant or borderline significant multiplicative and additive interactions were found between p53 rs2078486 polymorphism with smoking and indoor air pollution exposure. The variant genotype of p53 SNP rs1042522 significantly increased lung cancer risk in the total population (OR: 1.57, 95% CI: 1.11-2.21), but there was no evidence of heterogeneity among individuals with different lifestyle factors. Conclusion: This study confirmed that p53 rs2078486 SNP is potentially a novel functional p53 SNP that may affect lung cancer risk. Our study also suggested potential synergetic effects of p53 rs2078486 SNP with smoking and indoor air pollution exposure on lung cancer risk. Citation Format: Yanli Li, Shen-Chih Chang, Rungui Niu, Li Liu, Christina R. Crabtree-Ide, Baoxing Zhao, Jianping Shi, Xiaoyou Han, Jiawei Li, Jia Su, Lin Cai, Shunzhang Yu, Zuo-Feng Zhabg, Lina Mu. P53 genetic polymorphisms, interactions with lifestyle factors and lung cancer risk in a Chinese population. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-22. doi:10.1158/1538-7445.AM2013-LB-22