PP101-SUN: Maximum Grip Strength Predicts Major Complications in the First 30 Days After Elective Tumor Surgery in Old Patients – Data from the Peratecs Study

counseling is beneficial to nutritional status, QoL and survival in AL. Methods: In this single-center, randomized, controlled trial, 144 adult AL treatment naive outpatients were randomized to ad libitum food intake (usual care; N = 72) and nutritional counseling (N = 72). The primary endpoint was body weight change at 12 months. Secondary endpoints included change in QoL (SF-36) and survival. Results: Forty-one patients (N = 25 usual care, N = 16 nutritional counseling) died before the first follow-up visit. In the modified intention-to-treat population (patients who underwent at least one control visit [month 3]; N = 103), the difference in body weight between groups was not significant (weight loss [WL] difference = 1.6 kg [95%CI, 0.5, 3.6]; P= 0.137). However, patients assigned to nutritional counseling maintained a stable body weight ([N = 56]; WL = 0.8±4.9 kg; P= 0.214), whereas in the usual care group a significant decrease was observed ([N = 47]; WL = 2.4±5.5 kg; P= 0.003). A significant increase in the mental component summary of QoL was found in patients randomized to nutritional counselling (8.1 [95%CI: 2.3, 13.9]; P= 0.007). In the randomized population, nutritional counselling was significantly associated with improved survival (HR = 0.57 [95%CI: 0.35, 0.94]; P= 0.028). In a multivariable model, adjusted for baseline BMI, hematologic response and cardiac stage, a trend in reduced mortality was still observed for patients assigned to nutritional counseling (HR = 0.62 [95%CI: 0.37, 1.05]; P= 0.074). Conclusion: In AL outpatients, nutritional counseling is helpful in maintaining nutritional status, may positively affect survival and is effective in improving mental quality of life.