Cerebrospinal fluid substance P concentrations are elevated in patients with Alzheimer's disease

Per Johansson,Erik G Almqvist,Anders Wallin,Janove Johansson,Ulf Andreasson,Kaj Blennow,Henrik Zetterberg,Johan Svensson

Neuroscience Letters（2015）

引用 16|浏览39

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摘要

•Cross-sectional study of 60 patients and 20 matched controls.•Neuropeptides were measured in cerebrospinal fluid (CSF).•CSF substance P level was increased in Alzheimer's disease (AD).•Substance P correlated with β-amyloid1–42 (Aβ1–42) in CSF of AD patients.•CSF orexin A level was marginally reduced in other dementias.

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关键词

Alzheimer’s,disease,Cerebrospinal fluid,Dementia,Substance P,Orexin A,Neurotensin

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