Toward the total synthesis of a lagunamide B analogue

Tetrahedron Letters（2014）

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摘要

Lagunamides, isolated from a marine cyanobacterium Lyngbya majuscule found in Singapore, showed very potent activities against Plasmodium falciparum and murine leukemia cell line (P388). Herein, a concise synthetic approach toward the total synthesis of a lagunamide B analogue is discussed. Macrolactonization, HWE-olefination, and modified Crimmin’s aldol are some of the key reactions featured in this synthesis.

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关键词

Macrolactonization,Macrolactamization,Horner–Wadsworth–Emmons olefination,Crimmin’s aldol,2-Methyl-6-nitrobenzoic anhydride (MNBA)

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