A novel approach for the synthesis of α-aminonitriles using Mitsunobu’s reagent under solvent-free conditions
Tetrahedron Letters(2012)
摘要
A highly efficient, one-pot, three-component, solvent-free protocol for the synthesis of α-aminonitriles starting from their corresponding carbonyl compounds, amines, using Mitsunobu’s reagent has been developed. Diversity of α-aminonitriles has been synthesized in good to excellent yields (80–99%) using various kinds of aldehydes/ketones and a variety of amines.
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关键词
α-Aminonitriles,Carbonyl compounds,Amines,Strecker’s synthesis,Mitsunobu’s reagent
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