PEG grafted AM SURE™ resin and its application to solid-phase peptide synthesis

PEGylated core–shell type resin (PEG-AM SURE) was developed by modifying the surface of AM SURE™ resin with diamino PEG. The conditions for the PEG coupling reaction were optimized by adjusting PEG chain cross-linking and the amount of free amino groups to ensure a enough loading level of functional groups on the resin (>0.30–0.39mmolNH2/g). The resulting PEG-AM SURE resin showed better performance than conventional resins during solid-phase peptide synthesis of JR10-mer and β2m58–69 12-mer.