Tu1426 Endoscopic Submucosal Dissection (ESD) of Large Sessile and Flat Neoplastic Lesions in the Colon: a Single-Center Series with 83 Procedures from Europe

Endoscopic resection of sessile or flat colorectal neoplasia larger than 20mm is usually performed as piecemeal endoscopic mucosal resection (EMR). The disadvantage is the uncertainty of complete resection with reported recurrence rates between 20-30%. In contrast, endoscopic submucosal dissection (ESD) allows en bloc resection of larger sessile or flat lesions. Colorectal ESD is technically demanding and a higher perforation rate has been reported. Currently, there is little experience with this technique in the US and in Europe with only a few series of ESD in the rectum and sigmoid colon and virtually no data on ESD in the proximal colon. The study aimed at the evaluation of efficacy and safety of this method in a western setting.