1139 A Single Session of Intralesional Steroid Injection to Prevent Esophageal Stricture after Endoscopic Submucosal Dissection for Esophageal Squamous Cell Carcinoma

Stricture is a major complication after endoscopic submucosal dissection (ESD). Multivariate analysis has shown that a >3/4 circumference mucosal defect is a reliable predictor of stricture. The frequency of stricture after ESD for esophageal cancer with a high-risk >3/4 circumference mucosal defect is 70-90%. Post-ESD stricture substantially decreases the patients' quality of life, and requires treatment with multiple endoscopic balloon dilation (EBD) sessions. We administered a single session of local steroid injection immediately after ESD to effectively suppress inflammation from the initial phase.