What Can We Learn from Interventions That Change Fat Distribution?

Epidemiological studies have illustrated convincingly that fat distribution is associated with cardiometabolic risk. Fat deposition preferentially in the lower body, commonly seen in premenopausal women, is associated with lower risk, while central obesity in men and postmenopausal women is associated with higher risk. Studies of the physiology and the tissue and cellular characteristics of different adipose tissue depots, visceral and abdominal, gluteal, and femoral subcutaneous, corroborate this idea. In this report, we chose to focus on interventions—surgical, hormonal, lifestyle, and pharmacological—that directly or indirectly affect fat distribution, seeking further evidence for its pathophysiological significance.