Extra-helical binding site of a glucagon receptor antagonist

Ali Jazayeri,Andrew S. Doré,Daniel Lamb,Harini Krishnamurthy,Stacey M. Southall,Asma H. Baig,Andrea Bortolato,Markus Koglin,Nathan J. Robertson,James C. Errey,Stephen P. Andrews, Iryna Teobald,Alastair J. H. Brown,Robert M. Cooke,Malcolm Weir,Fiona H. Marshall

NATURE（2016）

引用 204|浏览24

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摘要

The X-ray crystal structure of the transmembrane portion of the human glucagon receptor, a class B G-protein-coupled receptor (GPCR), is solved in the presence of the antagonist MK-0893, with potential implications for the development of therapeutics that target other class B GPCRs.

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关键词

X-ray crystallography,G protein-coupled receptors

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