Exogenous BDNF increases neurogenesis in the hippocampus in experimental Streptococcus pneumoniae meningitis.

Di Lian,Dake He,Jing Wu,Ying Liu,Mingjie Zhu,Jiaming Sun,Feng Chen,Ling Li

Journal of Neuroimmunology（2016）

引用 25|浏览11

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摘要

•Bacterial meningitis could activate proliferation of endogenous NSCs in hippocampus.•Bacterial meningitis also impairs early differentiation of endogenous NSCs at the same time.•Exogenous BDNF could improve neurogenesis of endogenous NSCs in the DG of hippocampus.•BDNF treatment might be a promising therapy following bacterial meningitis.

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关键词

Streptococcus pneumoniae meningitis,Brain-derived neurotrophic factor,Neural stem cells,Endogenous neurogenesis

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