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CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas,Mathias L Richard,Valentin Leducq,Hang-Phuong Pham,Marie-Laure Michel,Gregory Da Costa,Chantal Bridonneau,Sarah Jegou,Thomas W Hoffmann,Jane M Natividad,Loic Brot,Soraya Taleb,Aurélie Couturier-Maillard,Isabelle Nion-Larmurier,Fatiha Merabtene,Philippe Seksik,Anne Bourrier,Jacques Cosnes,Bernhard Ryffel,Laurent Beaugerie,Jean-Marie Launay,Philippe Langella,Ramnik J Xavier,Harry Sokol

NATURE MEDICINE（2016）

引用 937|浏览46
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摘要
Metabolism of tryptophan by the gut microbiota is impaired by deficiencies in CARD9 , leading to the worsening of colitis.
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关键词
Inflammatory bowel disease,Mucosal immunology
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