Challenges in liquid chromatographic characterization of proteins.

Journal of Chromatography B（2016）

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摘要

•Stability of therapeutic proteins during liquid chromatography is overviewed.•Instrument inertness in terms of protein adsorption and chemical resistance is evaluated.•On-column protein adsorption and recent method development trends are reported.

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关键词

Sample stability,Protein chromatography,Adsorption,Method development,RPLC,IEX,SEC,HIC

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