Impact of pre-adapted HIV transmission Jonathan M Carlson , Victor Y Du , Nico Pfeifer , Anju Bansal , Vincent Y F Tan , Karen Power , Chanson J Brumme , Anat Kreimer , Charles E DeZiel , Nicolo Fusi , Malinda Schaefer , Mark A Brockman , Jill Gilmour , Matt A Price , William Kilembe , Richard Haubrich , Mina John , Simon Mallal , Roger Shapiro , John Frater , P Richard Harrigan , Thumbi Ndung'u , Susan Allen , David Heckerman , John Sidney , Todd M Allen , Philip J R Goulder , Zabrina L Brumme , Eric Hunter , Paul A Goepfert NATURE MEDICINE（2016）
摘要
Jonathan Carlson and colleagues report that pre-adaptation of HIV to a recipient's major histocompatibility complex class I alleles impairs immune control of the virus.
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关键词
Cellular immunity, Evolutionary genetics, Immune evasion, Computational models, Vaccines
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