Protecting genome integrity during CRISPR immune adaptation

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

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摘要

Cas1–Cas2 integrase achieves full-site integration only for proper targets and protospacers, whereas at non-CRISPR sites, integration stalls at the half-site intermediate, thereby protecting host genome integrity during CRISPR immune adaptation.

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关键词

DNA-binding proteins,DNA,Enzyme mechanisms,Transposition

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