A family of metal-dependent phosphatases implicated in metabolite damage-control

Lili Huang,Anna Khusnutdinova,Boguslaw Nocek,Greg Brown,Xiaohui Xu,Hong Cui,Pierre Petit,Robert Flick,Rémi Zallot,Kelly Balmant,Michael J Ziemak,John Shanklin,Valérie de Crécy-Lagard,Oliver Fiehn,Jesse F Gregory III,Andrzej Joachimiak,Alexei Savchenko,Alexander F Yakunin,Andrew D Hanson

NATURE CHEMICAL BIOLOGY（2016）

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摘要

Characterization of three DUF89 subfamilies representing all domains of life reveals that members function as metal-dependent phosphatases that help eliminate a wide range of damaged phosphometabolites.

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关键词

Metabolism,Enzyme mechanisms,Enzymes,X-ray crystallography

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