The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Georg B Ehret,Teresa Ferreira,Daniel I Chasman,Anne U Jackson,Ellen M Schmidt,Toby Johnson,Gudmar Thorleifsson,Jian'an Luan,Louise A Donnelly,Stavroula Kanoni,Ann-Kristin Petersen,Vasyl Pihur,Rona J Strawbridge,Dmitry Shungin,Maria F Hughes,Osorio Meirelles,Marika Kaakinen,Nabila Bouatia-Naji,Kati Kristiansson,Sonia Shah,Marcus E Kleber,Xiuqing Guo,Leo-Pekka Lyytikäinen,Cristiano Fava,Niclas Eriksson,Ilja M Nolte,Patrik K Magnusson,Elias L Salfati,Loukianos S Rallidis,Elizabeth Theusch,Andrew J P Smith,Lasse Folkersen,Kate Witkowska,Tune H Pers,Roby Joehanes,Stuart K Kim, Lazaros Lataniotis,Rick Jansen,Andrew D Johnson,Helen Warren,Young Jin Kim,Wei Zhao,Ying Wu,Bamidele O Tayo,Murielle Bochud,Devin Absher,Linda S Adair, Najaf Amin,Dan E Arking,Tomas Axelsson,Damiano Baldassarre,Beverley Balkau,Stefania Bandinelli,Michael R Barnes,Inês Barroso,Stephen Bevan,Joshua C Bis,Gyda Bjornsdottir,Michael Boehnke,Eric Boerwinkle,Lori L Bonnycastle, Dorret I Boomsma,Stefan R Bornstein,Morris J Brown,Michel Burnier,Claudia P Cabrera,John C Chambers,I-Shou Chang,Ching-Yu Cheng,Peter S Chines,Ren-Hua Chung,Francis S Collins,John M Connell,Angela Döring,Jean Dallongeville,John Danesh,Ulf de Faire,Graciela Delgado,Anna F Dominiczak,Alex S F Doney,Fotios Drenos,Sarah Edkins,John D Eicher,Roberto Elosua,Stefan Enroth,Jeanette Erdmann,Per Eriksson,Tonu Esko,Evangelos Evangelou,Alun Evans,Tove Fall,Martin Farrall,Janine F Felix,Jean Ferrières,Luigi Ferrucci,Myriam Fornage,Terrence Forrester,Nora Franceschini,Oscar H Franco,Anders Franco-Cereceda,Ross M Fraser,Santhi K Ganesh,He Gao,Karl Gertow,Francesco Gianfagna,Bruna Gigante,Franco Giulianini,Anuj Goel,Alison H Goodall,Mark O Goodarzi,Mathias Gorski, Jürgen Gräßler,Christopher J Groves,Vilmundur Gudnason,Ulf Gyllensten,Göran Hallmans,Anna-Liisa Hartikainen,Maija Hassinen,Aki S Havulinna,Caroline Hayward,Serge Hercberg,Karl-Heinz Herzig,Andrew A Hicks,Aroon D Hingorani,Joel N Hirschhorn,Albert Hofman,Jostein Holmen,Oddgeir Lingaas Holmen,Jouke-Jan Hottenga, Phil Howard,Chao A Hsiung,Steven C Hunt,M Arfan Ikram,Thomas Illig,Carlos Iribarren,Richard A Jensen,Mika Kähönen,Hyun Min Kang,Sekar Kathiresan,Brendan J Keating,Kay-Tee Khaw,Yun Kyoung Kim,Eric Kim,Mika Kivimaki,Norman Klopp,Genovefa Kolovou,Pirjo Komulainen,Jaspal S Kooner, Gulum Kosova,Ronald M Krauss,Diana Kuh,Zoltan Kutalik,Johanna Kuusisto,Kirsti Kvaløy,Timo A Lakka,Nanette R Lee,I-Te Lee,Wen-Jane Lee,Daniel Levy,Xiaohui Li,Kae-Woei Liang,Honghuang Lin,Li Lin,Jaana Lindström,Stéphane Lobbens,Satu Männistö,Gabriele Müller,Martina Müller-Nurasyid,François Mach,Hugh S Markus,Eirini Marouli,Mark I McCarthy,Colin A McKenzie,Pierre Meneton,Cristina Menni,Andres Metspalu,Vladan Mijatovic,Leena Moilanen,May E Montasser,Andrew D Morris,Alanna C Morrison,Antonella Mulas,Ramaiah Nagaraja,Narisu Narisu,Kjell Nikus,Christopher J O'Donnell,Paul F O'Reilly,Ken K Ong,Fred Paccaud,Cameron D Palmer,Afshin Parsa,Nancy L Pedersen,Brenda W Penninx,Markus Perola,Annette Peters,Neil Poulter,Peter P Pramstaller, Bruce M Psaty,Thomas Quertermous,Dabeeru C Rao,Asif Rasheed,N William Rayner,Frida Renström,Rainer Rettig,Kenneth M Rice,Robert Roberts,Lynda M Rose,Jacques Rossouw,Nilesh J Samani,Serena Sanna,Jouko Saramies,Heribert Schunkert,Sylvain Sebert, Wayne H-H Sheu,Young-Ah Shin,Xueling Sim,Johannes H Smit,Albert V Smith,Maria X Sosa,Tim D Spector,Alena Stančáková,Alice V Stanton,Kathleen E Stirrups,Heather M Stringham,Johan Sundstrom,Amy J Swift,Ann-Christine Syvänen,E-Shyong Tai,Toshiko Tanaka,Kirill V Tarasov,Alexander Teumer,Unnur Thorsteinsdottir,Martin D Tobin,Elena Tremoli,Andre G Uitterlinden,Matti Uusitupa,Ahmad Vaez,Dhananjay Vaidya,Cornelia M van Duijn,Erik P A van Iperen,Ramachandran S Vasan,Germaine C Verwoert,Jarmo Virtamo,Veronique Vitart,Benjamin F Voight,Peter Vollenweider,Aline Wagner,Louise V Wain, Nicholas J Wareham,Hugh Watkins,Alan B Weder,Harm-Jan Westra,Rainford Wilks,Tom Wilsgaard, James F Wilson,Tien Y Wong,Tsun-Po Yang,Jie Yao,Loic Yengo, Weihua Zhang, Jing Hua Zhao,Xiaofeng Zhu,Pascal Bovet,Richard S Cooper,Karen L Mohlke,Danish Saleheen,Jong-Young Lee,Paul Elliott,Hinco J Gierman,Cristen J Willer,Lude Franke,G Kees Hovingh,Kent D Taylor,George Dedoussis, Peter Sever,Andrew Wong,Lars Lind,Themistocles L Assimes,Inger Njølstad,Peter E H Schwarz,Claudia Langenberg,Harold Snieder,Mark J Caulfield,Olle Melander,Markku Laakso,Juha Saltevo,Rainer Rauramaa,Jaakko Tuomilehto,Erik Ingelsson,Terho Lehtimäki,Kristian Hveem,Walter Palmas,Winfried März,Meena Kumari,Veikko Salomaa, Yii-Der I Chen,Jerome I Rotter,Philippe Froguel,Marjo-Riitta Jarvelin,Edward G Lakatta,Kari Kuulasmaa,Paul W Franks,Anders Hamsten,H-Erich Wichmann,Colin N A Palmer,Kari Stefansson,Paul M Ridker, Ruth J F Loos,Aravinda Chakravarti,Panos Deloukas,Andrew P Morris,Christopher Newton-Cheh,Patricia B Munroe
Nature Genetics（2016）
引用 429|浏览2265
摘要
Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis -regulatory elements, particularly in vascular endothelial cells.
更多查看译文
AI 理解论文
溯源树
样例
生成溯源树，研究论文发展脉络
Chat Paper
正在生成论文摘要