Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Praveen Surendran,Fotios Drenos,Robin Young,Helen Warren,James P Cook,Alisa K Manning,Niels Grarup,Xueling Sim,Daniel R Barnes,Kate Witkowska,James R Staley,Vinicius Tragante,Taru Tukiainen,Hanieh Yaghootkar, Nicholas Masca,Daniel F Freitag,Teresa Ferreira,Olga Giannakopoulou,Andrew Tinker,Magdalena Harakalova,Evelin Mihailov,Chunyu Liu,Aldi T Kraja,Sune Fallgaard Nielsen,Asif Rasheed,Maria Samuel,Wei Zhao,Lori L Bonnycastle,Anne U Jackson,Narisu Narisu,Amy J Swift,Lorraine Southam,Jonathan Marten,Jeroen R Huyghe,Alena Stančáková,Cristiano Fava,Therese Ohlsson,Angela Matchan,Kathleen E Stirrups,Jette Bork-Jensen,Anette P Gjesing,Jukka Kontto,Markus Perola, Susan Shaw-Hawkins,Aki S Havulinna,He Zhang,Louise A Donnelly,Christopher J Groves,N William Rayner,Matt J Neville,Neil R Robertson,Andrianos M Yiorkas,Karl-Heinz Herzig,Eero Kajantie, Weihua Zhang,Sara M Willems,Lars Lannfelt,Giovanni Malerba,Nicole Soranzo,Elisabetta Trabetti,Niek Verweij,Evangelos Evangelou,Alireza Moayyeri,Anne-Claire Vergnaud,Christopher P Nelson,Alaitz Poveda,Tibor V Varga,Muriel Caslake,Anton J M de Craen,Stella Trompet,Jian’an Luan,Robert A Scott,Sarah E Harris,David C M Liewald,Riccardo Marioni,Cristina Menni,Aliki-Eleni Farmaki,Göran Hallmans,Frida Renström,Jennifer E Huffman,Maija Hassinen,Stephen Burgess,Ramachandran S Vasan,Janine F Felix, Maria Uria-Nickelsen,Anders Malarstig,Dermot F Reilly,Maarten Hoek,Thomas F Vogt,Honghuang Lin,Wolfgang Lieb,Matthew Traylor,Hugh S Markus,Heather M Highland,Anne E Justice,Eirini Marouli,Jaana Lindström,Matti Uusitupa,Pirjo Komulainen,Timo A Lakka,Rainer Rauramaa,Ozren Polasek,Igor Rudan,Olov Rolandsson,Paul W Franks,George Dedoussis,Timothy D Spector,Pekka Jousilahti,Satu Männistö, Ian J Deary,John M Starr,Claudia Langenberg,Nick J Wareham,Morris J Brown,Anna F Dominiczak,John M Connell,J Wouter Jukema,Naveed Sattar,Ian Ford,Chris J Packard,Tõnu Esko,Reedik Mägi,Andres Metspalu,Rudolf A de Boer,Peter van der Meer,Pim van der Harst,Giovanni Gambaro,Erik Ingelsson,Lars Lind,Paul I W de Bakker,Mattijs E Numans,Ivan Brandslund,Cramer Christensen,Eva R B Petersen, Eeva Korpi-Hyövälti,Heikki Oksa,John C Chambers,Jaspal S Kooner,Alexandra I F Blakemore,Steve Franks,Marjo-Riitta Jarvelin,Lise L Husemoen,Allan Linneberg,Tea Skaaby,Betina Thuesen,Fredrik Karpe,Jaakko Tuomilehto,Alex S F Doney,Andrew D Morris,Colin N A Palmer,Oddgeir Lingaas Holmen,Kristian Hveem,Cristen J Willer,Tiinamaija Tuomi,Leif Groop,AnneMari Käräjämäki,Aarno Palotie,Samuli Ripatti,Veikko Salomaa,Dewan S Alam, Abdulla al Shafi Majumder,Emanuele Di Angelantonio,Rajiv Chowdhury,Mark I McCarthy,Neil Poulter,Alice V Stanton,Peter Sever,Philippe Amouyel,Dominique Arveiler,Stefan Blankenberg,Jean Ferrières,Frank Kee,Kari Kuulasmaa,Martina Müller-Nurasyid,Giovanni Veronesi,Jarmo Virtamo,Panos Deloukas,Paul Elliott,Eleftheria Zeggini,Sekar Kathiresan,Olle Melander,Johanna Kuusisto,Markku Laakso,Sandosh Padmanabhan,David J Porteous,Caroline Hayward,Generation Scotland,Francis S Collins,Karen L Mohlke,Torben Hansen,Oluf Pedersen,Michael Boehnke,Heather M Stringham,Philippe Frossard,Christopher Newton-Cheh,Martin D Tobin,Børge Grønne Nordestgaard,Mark J Caulfield,Anubha Mahajan,Andrew P Morris,Maciej Tomaszewski,Nilesh J Samani,Danish Saleheen,Folkert W Asselbergs,Cecilia M Lindgren,John Danesh,Louise V Wain,Adam S Butterworth,Joanna M M Howson,Patricia B Munroe
Nature Genetics（2016）
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摘要
Patricia Munroe, Joanna Howson and colleagues genotype ∼350,000 individuals and identify 30 new blood pressure– or hypertension-associated risk loci. Their analyses provide insights into the pathophysiology of hypertension and highlight new potential targets for clinical intervention.
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