Lactate metabolism is associated with mammalian mitochondria

Ying-Jr Chen,Nathaniel G Mahieu,Xiaojing Huang,Manmilan Singh,Peter A Crawford,Stephen L Johnson,Richard W Gross,Jacob Schaefer,Gary J Patti

NATURE CHEMICAL BIOLOGY（2016）

引用 183|浏览19

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摘要

The application of high-resolution metabolomics integrated with isotope labeling revealed that lactate is imported into the mitochondria and is metabolized by mitochondrial LDH into pyruvate.

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关键词

Metabolomics,Metabolic pathways,Mass spectrometry

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