Sorafenib potentiates ABT-737-induced apoptosis in human oral cancer cells.

Lee-Han Kim,Ji-Ae Shin,Boonsil Jang,In-Hyoung Yang,Dong-Hoon Won,Joseph H Jeong,Tae-Ho Chung,Nam-Pyo Cho,Sung-Dae Cho

Archives of Oral Biology（2017）

引用 13|浏览15

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摘要

•Sorafenib synergistically kills oral cancer cells when combined with ABT-737.•Combination treatment induces the expression of Bax and Bak and their activation.•Inactivation of ERK and STAT3 may be associated with the synergy of combination treatment.

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关键词

Oral cancer,ABT-737,Sorafenib,Apoptosis,Bax,Bak

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