Activation of Nrf2-ARE signaling mitigates cyclophosphamide-induced myelosuppression.

Linling Que,Liu He, Chenshu Yu,Wencheng Yin,Liwen Ma,Baoshan Cao,Siwang Yu

Toxicology Letters（2016）

引用 12|浏览17

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摘要

•Nrf2 deficiency deteriorated CTX-induced myelosuppression in vitro/in vivo.•Nrf2 deficiency decreased antioxidant capacity of peripheral blood and bone marrow.•Nrf2 deficiency impaired hematopoietic proliferating and colony formation ability.•CDDO-Me Nrf2-dependently mitigated CTX-induced myelosuppression.

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关键词

Nrf2,G-CSF,HSCs,HPCs,3LL,RBC,DPPH,TOSC,TAOC,LDCL,PBMC,SCF,CDDO-Me

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