Active DNA demethylation at enhancers during the vertebrate phylotypic period

Ozren Bogdanović,Arne H Smits,Elisa de la Calle Mustienes,Juan J Tena,Ethan Ford, Ruth Williams,Upeka Senanayake,Matthew D Schultz,Saartje Hontelez, Ila van Kruijsbergen,Teresa Rayon,Felix Gnerlich,Thomas Carell,Gert Jan C Veenstra,Miguel Manzanares,Tatjana Sauka-Spengler,Joseph R Ecker,Michiel Vermeulen,José Luis Gómez-Skarmeta,Ryan Lister

NATURE GENETICS（2016）

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摘要

Ozren Bogdanović, Ryan Lister, José Luis Gómez-Skarmeta, Michiel Vermeulen and colleagues report widespread DNA demethylation at developmental enhancers during the phylotypic period in zebrafish, Xenopus and mouse embryos. Their findings suggest a conserved role for Tet proteins and active DNA demethylation in the regulation of phylotypic enhancers.

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关键词

Epigenetics,Epigenomics,Embryogenesis

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