OS 22-05 Variability of urinary salt excretion in treated hypertensive patients during several years.

To investigate the average and variability in urinary salt excretion in treated hypertensive outpatients during several years (median follow-up is 2 years).In our previous research, the subjects were 200 hypertensive patients who underwent at least three measurement of USALT from Sep 2012 to Mar 2013. We extended the follow-up period until Aug 2015 and the subjects were 68 hypertensive patients who were measured USALT 10 times over (65.1 ± 10.2 years old, Female 32.4%). The mean of 10 times USALT and coefficient of variation (CV) for USALT were calculated and investigated the relationship with age, sex, antihypertensive medication, comorbidities.During the median period of 2 years, USALT measurement was an average of 14.8 times. Comorbidities of patients were CKD 63.2%, diabetes mellitus 45.6%, dyslipidemia 55.9% and hyperuricemia 54.5%, respectively. The subjects who have complication or past history of vascular disease (ex. Brain infarction) were 36.8%. The average of USALT until 10 times was 8.66 g/day and CV of USALT (median) was 16.6%. Subjects in large USALT group (≧ 8.66 g/day) were higher BMI (26.0 v.s 24.1 Kg/m2, p < 0.05), lower HDL-C (45.1 v.s 51.5 mg/dl, p < 0.05), more often be prescribed with α 1-blockers (44.1 v.s 20.6%, p < 0.05) and diuretics (35.3 v.s 11.8%, p < 0.05) than small USALT group (< 8.66 g/day). There are more female than men (48.5 v.s 17.1%, P < 0.05) and tendency to have a vascular disease (45.5 v.s 25.7%, P = 0.09) in high CV of USALT group (≧ 16.7%) than low group (< 16.7%).This study show that the average of USALT was related to BMI and drug-resistant hypertension in accordance with past report. In addition, sex is possible to be associated with variability of USALT during 2 year follow-up.