A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange

Byung Ran So,Lili Wan,Zhenxi Zhang,Pilong Li, Eric Babiash,Jingqi Duan,Ihab Younis,Gideon Dreyfuss

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

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摘要

The higher abundance of U1 among snRNPs is explained by the identification of an additional mode of assembly: RBP U1-70K bridges pre-U1 to SMN–Gemin2–Sm, thus establishing a Gemin5-independent assembly pathway.

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Biochemistry,Molecular biology

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