A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation

Rafael D Acemel,Juan J Tena,Ibai Irastorza-Azcarate,Ferdinand Marlétaz,Carlos Gómez-Marín,Elisa de la Calle-Mustienes,Stéphanie Bertrand, Sergio G Diaz,Daniel Aldea,Jean-Marc Aury,Sophie Mangenot,Peter W H Holland,Damien P Devos,Ignacio Maeso,Hector Escrivá,José Luis Gómez-Skarmeta

NATURE GENETICS（2016）

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摘要

José Luis Gómez-Skarmeta, Hector Escrivá, Ignacio Maeso, Damien Devos and colleagues perform 4C-seq profiling of the Hox cluster in amphioxus embryos and find that, unlike in vertebrate embryos, the cluster is organized into a single chromatin interaction domain. They suggest that the vertebrate Hox bipartite regulatory system is an evolutionary novelty.

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关键词

Gene regulation,Epigenomics

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