An inducible long noncoding RNA amplifies DNA damage signaling

Adam M Schmitt,Julia T Garcia,Tiffany Hung,Ryan A Flynn,Ying Shen,Kun Qu,Alexander Y Payumo, Ashwin Peres-da-Silva,Daniela Kenzelmann Broz,Rachel Baum,Shuling Guo,James K Chen,Laura D Attardi,Howard Y Chang

NATURE GENETICS（2016）

引用 197|浏览7

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摘要

Howard Chang and colleagues identify a long noncoding RNA, DINO, that is transcribed upstream of CDKN1A and induced by p53 in response to DNA damage. They show that DINO binds to p53 protein and promotes its stabilization, producing a feedback loop that amplifies DNA damage signaling.

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关键词

Molecular biology,Gene regulation,Cell biology

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