Local regulation of gene expression by lncRNA promoters, transcription and splicing

Jesse M. Engreitz,Jenna E. Haines,Elizabeth M. Perez,Glen Munson,Jenny Chen,Michael Kane,Patrick E. McDonel,Mitchell Guttman,Eric S. Lander

NATURE（2016）

引用 1176|浏览64

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摘要

Various cis -regulatory functions of genomic loci that produce long non-coding RNAs are revealed, including instances where their promoters have enhancer-like activity and the lncRNA transcripts themselves are not required for activity.

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关键词

Functional genomics,Gene expression,Gene regulation,Long non-coding RNAs,Transcriptional regulatory elements,Science,Humanities and Social Sciences,multidisciplinary

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