Targeting the histone methyltransferase G9a activates imprinted genes and improves survival of a mouse model of Prader–Willi syndrome

Yuna Kim,Hyeong-Min Lee,Yan Xiong,Noah Sciaky,Samuel W Hulbert,Xinyu Cao,Jeffrey I Everitt,Jian Jin,Bryan L Roth,Yong-hui Jiang

NATURE MEDICINE（2016）

引用 85|浏览7

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摘要

pharmacological screen has identified the histone methyltransferase G9a as a target to reactivate imprinted genes in a mouse model of Prader–Willi Syndrome that improves growth and survival.

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关键词

Cancer metabolism,Cancer screening

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