Themis2 lowers the threshold for B cell activation during positive selection

Daian Cheng,Mukta Deobagkar-Lele,Ekaterina Zvezdova,Seeyoung Choi,Shoji Uehara, Delphine Baup,Sophia C Bennett,Katherine R Bull,Tanya L Crockford,Helen Ferry,Claude Warzecha,Marlène Marcellin,Anne Gonzalez de Peredo,Renaud Lesourne,Consuelo Anzilotti,Paul E Love,Richard J Cornall

Nature Immunology（2016）

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摘要

Cornall and colleagues show that Themis2 interacts with the phospholipase PLC-γ2 and lowers the threshold for B cell activation by low but not high avidity antigens.

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关键词

B cells,Humoral immunity,Biomedicine,general,Immunology,Infectious Diseases

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