Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)

Mariana Grieben,Ashley C W Pike,Chitra A Shintre,Elisa Venturi,Sam El-Ajouz,Annamaria Tessitore,Leela Shrestha,Shubhashish Mukhopadhyay,Pravin Mahajan,Rod Chalk,Nicola A Burgess-Brown,Rebecca Sitsapesan,Juha T Huiskonen,Elisabeth P Carpenter

NATURE STRUCTURAL & MOLECULAR BIOLOGY（2016）

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摘要

The cryo-EM structure of human polycystin-2 (PC2) in a closed conformation reveals a domain located above the pore filter, forming an upper vestibule and making contacts with the pore and voltage-sensor-like domains.

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关键词

Cryoelectron microscopy,Transient receptor potential channels

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