Rewiring human cellular input–output using modular extracellular sensors

Kelly A Schwarz,Nichole M Daringer,Taylor B Dolberg,Joshua N Leonard

Nature Chemical Biology（2016）

引用 88|浏览5

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摘要

Synthetic biology enables re-engineering of cellular functions by introduction of modular, orthogonal signaling pathways, as illustrated by the reprogramming of human T cells to produce IL-2 in response to vascular endothelial growth factor (VEGF).

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关键词

Cell signalling,Immunology,Protein design,Synthetic biology,Chemistry/Food Science,general,Biochemical Engineering,Biochemistry,Cell Biology,Bioorganic Chemistry

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