A human microprotein that interacts with the mRNA decapping complex

Nadia G D'Lima,Jiao Ma,Lauren Winkler,Qian Chu,Ken H Loh,Elizabeth O Corpuz,Bogdan A Budnik,Jens Lykke-Andersen,Alan Saghatelian,Sarah A Slavoff

NATURE CHEMICAL BIOLOGY（2016）

引用 178|浏览30

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摘要

Mass-spectrometry-based proteomics led to the identification of NoBody, a microprotein translated from LINC01420 RNA, which interacts with enhancer of decapping 4 (EDC4) and negatively regulates 5′-to-3′ mRNA decay.

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关键词

RNA metabolism,Peptides,Mass spectrometry,Non-coding RNAs

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