A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish

Gaurav K Varshney,Blake Carrington,Wuhong Pei,Kevin Bishop,Zelin Chen,Chunxin Fan,Lisha Xu,Marypat Jones,Matthew C LaFave,Johan Ledin,Raman Sood,Shawn M Burgess

NATURE PROTOCOLS（2016）

引用 147|浏览38

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摘要

The Burgess laboratory describes their functional genomics pipeline based on CRISPR/Cas9-targeted mutagenesis in zebrafish. The system is scalable, enabling phenotypic screening of hundreds of targeted mutants.

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关键词

Mutagenesis,Genetic engineering,CRISPR-Cas9 genome editing,Zebrafish

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