Early antibody therapy can induce long-lasting immunity to SHIV

Yoshiaki Nishimura,Rajeev Gautam,Tae-Wook Chun,Reza Sadjadpour,Kathryn E. Foulds,Masashi Shingai,Florian Klein,Anna Gazumyan,Jovana Golijanin,Mitzi Donaldson,Olivia K. Donau,Ronald J. Plishka,Alicia Buckler-White,Michael S. Seaman,Jeffrey D. Lifson,Richard A. Koup,Anthony S. Fauci,Michel C. Nussenzweig,Malcolm A. Martin

NATURE（2017）

引用 224|浏览12

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摘要

Early administration of broadly neutralizing antibodies in a macaque SHIV infection model is associated with very low levels of persistent viraemia, which leads to the establishment of T-cell immunity and resultant long-term infection control.

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Retrovirus,HIV infections

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