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Photochemical and DNA Degradation Studies on Tenoxicam, Lornoxicam, and Their Photolysis Products

Ibrahim Elghamry,Usama El-Ayaan,Magdy M. Youssef,Shar Al-Shihry,Matthias Letzel,Jochen Mattay

Monatshefte für Chemie（2016）

Cited 4|Views2
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Abstract
Tenoxicam and lornoxicam are nonsteroidal anti-inflammatory drugs, were subjected to photoirradiation at 254 nm led to the photodegradation of the pharmaceutical agents. Both, the isolated photodegradation products and the pharmaceutical agents were examined toward DNA binding and degradation. The photodegradation products degrade calf thymus in concentration dependent manner.
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Key words
Oxicams,Photostability,Photodegradation,Zwitterionic effect,DNA degradation
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