Standard molar enthalpy of formation of [(C 12 H 8 N 2 ) 2 Bi(O 2 NO) 3 ] and its biological activity on Schizosaccharomyces pombe

The title complex [(C 12 H 8 N 2 ) 2 Bi(O 2 NO) 3 ] was synthesized by reaction of 1,10-phenanthroline (phen) and Bi(NO 3 ) 3 ·5H 2 O. The structure of the complex was characterized by single-crystal X-ray diffraction, IR spectroscopy, and elemental analysis. An advanced solution-reaction isoperibol microcalorimeter was applied to determine the standard molar enthalpies of formation at 298.15 K of the complex and Bi(NO 3 ) 3 ·5H 2 O, giving –(798.92 ± 5.99) and –(1986.87 ± 0.20) kJ mol −1 , respectively. The biological effect of the complex was evaluated by microcalorimetry on the growth of Schizosaccharomyces pombe ( S . pombe ). According to thermogenic curves, the corresponding thermokinetics and thermodynamic parameters were derived. The complex had good bioactivity on the growth metabolism of S . pombe , with the value of IC 50 being 2.8 × 10 −5 mol L −1 .